When Walter White, a New Mexico chemistry teacher, is diagnosed with Stage III cancer and given a prognosis of only two years left to live, he becomes filled with a sense of fearlessness and an unrelenting desire to secure his family's financial future at any cost as he enters the dangerous world of drugs and crime.
Walt faces a new threat on a new front and deals with an increasingly angry Skyler, who must consider what to do next with her life and the kids'. Meanwhile, Jesse comes face-to-face with some startling self-revelations.
Despite ever-increasing tension between Walt and Skyler, he pulls out all the stops in an effort to reconcile with the family. Elsewhere, Saul is instrumental in getting Jesse involved in a most-unusual investment opportunity.
Walt ignores Skyler's demands, furthering the rift between them and pushing her to break bad. Still suffering from panic and anxiety attacks, Hank crosses a line at work.
Walt loses control as he reacts to Skyler's news, endangering his job and relationships with Saul and Jesse. Hank throws himself into his blue meth investigation. Jesse enacts a new plan.
Gus increases his efforts to lure Walt back into business, forcing a rift between Walt and Jesse. Skyler doubts her new relationship. Marie confides in Skyler about her concern for Hank's well-being.
Walt settles into his new surroundings; Walt, Jr. wants answers about his parents' relationship; Hank's investigation causes problems for Walt and Jesse.
Hank's increasing volatility forces a confrontation with Jesse and trouble at work. Skyler pressures Walt to make a deal. Gus' actions have severe consequences.
The family waits for news about Hank. While Jesse covers at the lab, Walt attempts to placate Gus. After witnessing a disturbing outburst, Walt worries he and his family are in danger.
As Hank's hospital bills stack up, Skyler hatches a plan. Walt and Gus come to a better understanding. Jesse, looking for more independence, pursues a new opportunity.
Walt becomes obsessed with a contaminant in the lab and refuses to finish the cook until it is eliminated. A frustrated Jesse attempts to get Walt back on track.
Skyler gets involved with Walt's business while Hank struggles with recovery. Jesse has a startling discovery after meeting a girl at group therapy.
Against Walt's advice, Jesse lashes out . Fearing for Jesse's safety, Walt takes drastic action to intervene. A tragic event leads to a shocking confrontation.
With Jesse on the run and Mike in hot pursuit, Walt negotiates a bargain with Gus and concocts a disturbing plan to provide for his and Jesse's safety.