The Big Bang Theory is centered on five characters living in Pasadena, California: roommates Leonard Hofstadter and Sheldon Cooper; Penny, a waitress and aspiring actress who lives across the hall; and Leonard and Sheldon's equally geeky and socially awkward friends and co-workers, mechanical engineer Howard Wolowitz and astrophysicist Raj Koothrappali. The geekiness and intellect of the four guys is contrasted for comic effect with Penny's social skills and common sense.
Sheldon and Amy's honeymoon runs aground in New York. Penny and Leonard discover they are uncomfortably similar to Amy's parents. Raj insults physicist Neil deGrasse Tyson and starts a Twitter war.
Sheldon and Amy drive themselves crazy trying to figure out what 'perfect gift' Leonard and Penny gave them for their wedding. Raj decides he wants to settle down and asks his father to arrange a marriage for him.
The Wolowitzes' life gets complicated when Stuart starts bringing his new girlfriend home. Penny and Leonard talk about starting a family. Raj explores an arranged marriage.
When Sheldon won't tell anyone why he's never mentioned his childhood best friend, Leonard takes matters into his own hands. Bernadette and Penny take out Raj’s fiancée for dinner to get the skinny on her.
When Amy doesn’t have time to work on super-asymmetry, Sheldon goes to great lengths to ensure she’s available to work with him even it if means accidentally sabotaging her career in the process. Raj doesn’t want Howard to join him in hosting a show at the planetarium.
When Howard dresses up as Sheldon for Halloween, Sheldon seeks retaliation at Leonard and Penny's Halloween party. Leonard is shocked that Penny doesn't remember their first kiss.
Leonard is caught between a rock and a hard place when he's responsible for distributing extra grant money. Bernadette turns the backyard playhouse into a hideaway from Howard and the kids.
Sheldon tries to bond with Amy's father, but when Howard lures Mr. Fowler away with magic tricks, Sheldon has no choice but to bond with Mrs. Fowler. Raj and Anu try to get physical for the first time.
Sheldon and Amy are devastated after learning from a Russian paper that Super Asymmetry has already been discovered and disproven. Ultra-competitive Bernadette asks Stuart’s girlfriend to teach her how to beat Howard in a popular video game.
Sheldon and Amy are still down about their theory being disproven, but a VHS tape from Sheldon’s past inspires him not to give up. Bernadette turns into a pageant mom when she tries to help Howard ace his Magic Castle audition.